Исследования

Babystart® специализируется на разработке и производстве продуктов для Репродуктологии. Все продукты компании проходят тщательные клинические исследования в лучших репродуктивных центрах Европы. Так же, выходя на локальные рынки обязательно проводятся клинические исследования в ведущих репродуктивных центрах данной страны.Здесь вы можете ознакомится с европейскими и украинскими клиническими исследованиями наших продуктов и их компонентов:


FertilMan Plus


Эффективность FertilMan Plus™ была доказана на базе «Медицинского центра лечения бесплодия» (г. Черновцы) под наблюдением президента Украинской ассоциации репродуктивной медицины, д.м.н., профессора Юзько А.М. (СКАЧАТЬ ТЕКСТ ПУБЛИКАЦИИ ).

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

  1. L-карнитин: (см. Ссылку 1-4) 
  2. L-аргинин: (5-7) 
  3. Цинк: (8-10) 
  4. Селен: (11) 
  5. Витамин B12: (12,15) 
  6. Витамин A: (13-14) 
  7. Витамин C : (16-18) 
  8. Витамин Е: (19-21) 
  9. Глутатион: (21-24) 
  10. Коэнзим Q10: (25-26) 
  11. Витамин D: (27) 
  12. Витамин B1 (тиамин) (28-29)

(1) Costa M et al. L-Carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May-Jun;26(3):155-9

(2) Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-Carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl. 1992 Jun;64(2):187-96.

(3) Menchini-Fabris GF et al. Free L-Carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984 Aug;42(2):263-7.

(4) Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic.

(5) Scibona M et al. L-Arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.

(6) Schachter A et al. Treatment of oligospermia with the amino acid Arginine. Int J Gynaecol Obstet. 1973 Sep;11(5):206-9.

(7) Lewin, A et al. Studies on Arginine in human semen. 3. The influences of several drugs on male infertility. Bull Osaka Med Sch. 1967 Oct;13(2):90-100.

(8) Tikkiwal M et al. Effect of Zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4

(9) Takihara H, Cosentino MJ, Cockett AT. Zinc sulfate therapy for infertile male with or without varicocelectomy. Urology. 1987 Jun;29(6):638-41

(10) Madding CI, Jacob M, Ramsay VP, Sokol RZ. Serum and semen Zinc levels in normozoospermic and oligozoospermic men. Ann Nutr Metab. 1986;30(4):213-8.

(11) Moslemi, M et al. Selenium – Vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011;4:99-104

(12) Moriyama H, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hinyokika Kiyo. 1987 Jan;33(1):151-6.

(13) Hermes, R et al. Improvement of male fertility by long-term beta carotene supplementation in white rhinoceros. Institute for zoo and wildlife research, 2003.

(14) Almbro, M. et al. Effects of Vitamin E and beta-carotene on sperm competitiveness. Ecology Letters doi: 10.1111/j.1661-0248.2011.01653.x

(15) Sandler, B et al. The treatment of oligospermia with stilbestrol and vitamin B. Fertil Steril. 1961 Sep-Oct;12:469-73.

(16) C G Fraga, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 December 15; 88(24): 11003–11006.

(17) Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009 Sep;45(2):164-9.

(18) Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5)1034-9.

(19) Kessopoulou E et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.

(20) Geva E et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril. 1996 Sep;66(3):430-4.

(21) Shamsi, M.B., S. Venkatesh, M. Tanwar, P. Talwar, R.K. Sharma, A. Dhawan, R. Kumar, N.P. Gupta, N. Malhotra, and N. Singh. “DNA Integrity and Semen Quality in Men with Low Seminal Antioxidant Levels.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 665.1-2 (2009): 29-36. Print.

(22) Lenzi, A., F. Culasso, L. Gandini, F. Lombardo, and F. Dondero. “Placebo-controlled, Double-blind, Cross-over Trial of Glutathione Therapy in Male Infertility.” Hum. Reprod. 8.10 (1993): 1657-62. Print.

(23) Lenzi, A., F. Lombardo, L. Gandini, F. Culasso, and F. Dondero. “Glutathione Therapy for Male Infertility.” Arch Androl 29.1 (1992): 65-8. Print.

(24) Lenzi A et al. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.

(25) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19

(26) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19.

(27) Pilz S et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.

(28) Fleming JC et al. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking Thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct;80(1-2):234-41.

(29) Oishi K, et al. Male infertility due to germ cell apoptosis in mice lacking the Thiamin carrier, Tht1. A new insight into the critical role of Thiamin in spermatogenesis. Dev Biol. 2004 Feb 15;266(2):299-309.


FertilMan


Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

  1. L-карнитин: (см. ссылку 1-4)
  2. L-аргинин: (5-7)
  3. Цинк: (8-10)
  4. Селен: (11)
  5. Витамин В12: (12-13)
  6. Витамин С: (14-15)
  7. Витамин Е : (16-18)
  8. Глутатион: (19-22)
  9. Коэнзим Q10: (23-24)
  10. Витамин D3: (25)

(1) Costa M et al. L-Carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia. 1994 May-Jun;26(3):155-9

(2) Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-Carnitine: its possible role in sperm tail function. Arch Ital Urol Nefrol Androl. 1992 Jun;64(2):187-96.

(3) Menchini-Fabris GF et al. Free L-Carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984 Aug;42(2):263-7.

(4) Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic

(6) Schachter A et al. Treatment of oligospermia with the amino acid Arginine. Int J Gynaecol Obstet. 1973 Sep;11(5):206-9.

(7) Lewin, A et al. Studies on Arginine in human semen. 3. The influences of several drugs on male infertility. Bull Osaka Med Sch. 1967 Oct;13(2):90-100.

(8) Tikkiwal M et al. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4

(9) Takihara H, Cosentino MJ, Cockett AT. Zinc sulfate therapy for infertile male with or without varicocelectomy. Urology. 1987 Jun;29(6):638-41

(10) Madding CI, Jacob M, Ramsay VP, Sokol RZ. Serum and semen zinc levels in normozoospermic and oligozoospermic men. Ann Nutr Metab. 1986;30(4):213-8.

(11) Moslemi, M et al. Selenium – Vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011;4:99-104

 (12) Moriyama H, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hinyokika Kiyo. 1987 Jan;33(1):151-6.

(13) Sandler, B et al. The treatment of oligospermia with stilbestrol and vitamin B. Fertil Steril. 1961 Sep-Oct;12:469-73.

(16) C G Fraga, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 December 15; 88(24): 11003–11006.

(14) Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009 Sep;45(2):164-9.

(15) Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5):1034-9.

(16) Kessopoulou E et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31.

(17) Geva E et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.Fertil Steril. 1996 Sep;66(3):430-4.

(18) Aitken RJ et al. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl. 1989 May-Jun;10(3):216-20.

(19) Lenzi, A., F. Culasso, L. Gandini, F. Lombardo, and F. Dondero. “Placebo-controlled, Double-blind, Cross-over Trial of Glutathione Therapy in Male Infertility.” Hum. Reprod. 8.10 (1993): 1657-62. Print.

(20) Shamsi, M.B., S. Venkatesh, M. Tanwar, P. Talwar, R.K. Sharma, A. Dhawan, R. Kumar, N.P. Gupta, N. Malhotra, and N. Singh. “DNA Integrity and Semen Quality in Men with Low Seminal Antioxidant Levels.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 665.1-2 (2009): 29-36. Print.

(21) Lenzi, A., F. Lombardo, L. Gandini, F. Culasso, and F. Dondero. “Glutathione Therapy for Male Infertility.” Arch Androl 29.1 (1992): 65-8. Print.

(22) Lenzi A et al. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.

(23) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19 (5) Scibona M et al. L-Arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.

(24) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19 (25) Pilz S et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.


FertilCare


FertilCare™ проходил клиническое исследование на базе ЛНМУ имени Данила Галицкого (г. Львов). Факультет последипломного образования Кафедра акушерства, гинекологии и перинатологии, под наблюдением проф. Пироговой В.И. (СКАЧАТЬ ТЕКСТ ИССЛЕДОВАНИЯ)

Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

Пре-концептуальная мультивитаминная добавка (1,18)

  1. Магний: (2-3)
  2. L-аргинин: (4)
  3. Витамин C: (5-6)
  4. L-таурин: (7)
  5. Ниацин: (8)
  6. Железо: (9)
  7. Цинк / Медь: (10,12)
  8. Витамин Е: (13)
  9. Витамин B6: (14)
  10. Рибофлавин: (15-17)
  11. Фолиевая кислота: (10, 18-19)
  12. Витамин D3: (20-25)
  13. Витамин B12: (26 -28)

(1) Czeizel AE, Metneki J, Dudas I. The effect of pre-conceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res 1996;66:55–8

(2) Howard JM, Davies S, Hunnisett A. Red cell magnesium and glutathione peroxidase in infertile women–effects of oral supplementation with magnesium and selenium. Magnes Res. 1994 Mar;7(1):49-57.

(3) J am Coll Nutr. 2004 Dec;23(6):694S-700S. New data on the importance of gestational Mg deficiency. Durlach J

(4) Battaglia, C. et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum. Reprod. (1999) 16 (7): 1690-1697.

(5) M R Luck, I Jeyaseelan, R A Scholes. Ascorbic acid and fertility. Biology of Reproduction February 1, 1995 vol. 52 no. 2 262-266

(6) J. Millar. Vitamin c – the primate fertility factor? Medical Hypotheses, Volume 38, Issue 4, August 1992, Pages 292-295

(7) Aerts L, Van Assche FA. Taurine and taurine-deficiency in the perinatal period. J Perinat Med. 2002;30(4):281-6.

(8) Brent BE, Bartley EE. Thiamin and niacin in the rumen. Journal of Animal Science [1984, 59(3):813-822]

(9) Chavarro, Jorge E. MD, ScD1,2; Rich-Edwards, Janet W. MPH, ScD2,3,4; Rosner, Bernard A. PhD4,5; Willett, Walter C. MD, DrPH1,2,4. Iron Intake and Risk of Ovulatory Infertility. Obstetrics & Gynecology: November 2006 – Volume 108 – Issue 5 – pp 1165-1152

(10) Stang, J. PhD et al. Effects of Iron and Folic Acid Supplements on Serum Zinc Levels Among a Cohort of Pregnant Women. Clinical Nutrition September 2002 – Volume 17 – Issue 4 – p 15-26

(12) SOLTAN, M. H. and JENKINS, D. M. (1983), Plasma copper and zinc concentrations and infertility. BJOG: An International Journal of Obstetrics & Gynaecology, 90: 457–459

(13) Kaempf-Rotzoll, Daisy E.a,b; Traber, Maret G.c; Arai, Hiroyukia. Vitamin E and transfer proteins. Current Opinion in Lipidology: June 2003 – Volume 16 – Issue 3 – pp 249-254

(14) Durrane T. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane database of systematic reviews 2006, Issue 2. Art. No.:CD000179.

(15) Sigfried Heller, Richard M. Salkeld, and Wilhelm F. Körner. Riboflavin status in pregnancy. Am J Clin Nutr November 1974 vol. 27 no. 11 1225-1230.

(16) Jessica Chan, Liyuan Deng, Leonie G Mikael, Jian Yan, Laura Pickell, Qing Wu, Marie A Caudill, and Rima Rozen. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr April 2010 vol. 91 no. 4 1035-1043

(17) Powers HJ, Bates CJ. Effects of pregnancy and riboflavin deficiency on some aspects of iron metabolism in rats. Int J Vitam Nutr Res. 1984;54(2-3):179-83.

(18) E. Czeizel, I. Dudás, J. Métneki. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Archives of Gynecology and Obstetrics July 1994, Volume 255, Issue 3.

(19) Scholl. T, Johnson. W. Folic acid: influence on the outcome of pregnancy1,2,3,4. Am J Clin Nutr May 2000 vol. 71 no. 5 1295s-1303s.

(20) Christopher S Kovacs. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies1,2,3,4. Am J Clin Nutr August 2008 vol. 88 no. 2 520S-528S

(21) G. G. Kwiecinksi, G. I. Petrie, and H. F. DeLuca. 1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats. AJP – Endo April 1, 1989 vol. 256 no. 4 E483-E487.

(22) N.Q. Liu, M. Hewison. Vitamin D, the placenta and pregnancy. Archives of Biochemistry and Biophysics Volume 523, Issue 1, 1 July 2012, Pages 37–47.

(23) Lewis. S, et al. Vitamin D deficiency and pregnancy: From preconception to birth. Molecular Nutrition & Food Research Volume 54, Issue 8, pages 1092–1102, August 2010.

(24) Marya R.K, Lal H, Chugh K, Saini A.S. Effect of Vitamin D Administration during Pregnancy on Neonatal Growth in the Rat. Ann Nutr Metab 1989;33:261–265.

(25) Laura E. Johnson and Hector F. DeLuca2. Reproductive Defects Are Corrected in Vitamin D–Deficient Female Rats Fed a High Calcium, Phosphorus and Lactose Diet. j. Nutr. August 1, 2002 vol. 132 no. 8 2270-2273.

(26) B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep. Kanakkaparambil R, Singh R, Li D, Webb R, Sinclair KD. Biol Reprod. 2009 Apr;80(4):743-52.

(27) Bennett M. Vitamin B12 deficiency, infertility and recurrent fetal loss. J Reprod Med. 2001 Mar;46(3):209-12.

(28) Weiss, Rachel MD*; Fogelman, Yacov MD†; Bennett, Michael MBBS, FRCP, FRCPath. Severe Vitamin B12 Deficiency in an Infant Associated With a Maternal Deficiency and a Strict Vegetarian Diet. Journal of Pediatric Hematology/Oncology: April 2004 – Volume 26 – Issue 4 – pp 270-271.


FertilOva Plus


Исследования, которые могут вас заинтересовать (номера ссылок в скобках):

 Мио-инозитол, d-хиро-инозитол (1)